Na+ Action Potentials in Human Photoreceptors
نویسندگان
چکیده
منابع مشابه
Na+ Action Potentials in Human Photoreceptors
Mammalian photoreceptors are hyperpolarized by a light stimulus and are commonly thought to be nonspiking neurons. We used the whole-cell patch-clamp technique on surgically excised human retina to examine whether human photoreceptors can elicit action potentials. We discovered that human rod photoreceptors express voltage-gated Na(+) channels, and generate Na(+) action potentials, in response ...
متن کاملSuppression by an h current of spontaneous Na+ action potentials in human cone and rod photoreceptors.
PURPOSE The sense of vision in humans is robust, and visual flickering is rarely experienced. To investigate this mechanism, electrophysiological and molecular biological techniques were used on human cone and rod photoreceptors. METHODS Voltage-gated currents were recorded using the patch-clamp technique on isolated human cones, and especially their voltage-gated Na+ currents were analyzed i...
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Remarkably dynamic Ca z ÷ fluxes control Ca 2 ÷ homeostasis in the outer segments of vertebrate rod photoreceptors (ROS). Ca 2 ÷ fluxes are believed to be carried by only two different membrane proteins embedded in the ROS plasma membrane; these two proteins as well as some of the other main molecular components of ROS are schematically depicted in Fig. 1. ROS are the sites of the process of vi...
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Electrical potentials exist across the membranes of virtually all cells of the body. In addition, some cells, such as nerve and muscle cells, are capable of generating rapidly changing electrochemical impulses at their membranes, and these impulses are used to transmit signals along the nerve or muscle membranes. In other types of cells, such as glandular cells, macrophages, and ciliated cells,...
متن کاملAction Potentials'
lntracellular Caz+, K+, CI-, and NOsactivities were measured with ion-selective microeledrodes in the liverwort Conocephalum conicum 1. at rest, during dark/light changes, and in the couese of adion potentials triggered by light or electrical stimuli. l h e average free cytosolic Caz+ concentration was 231 f 65 nM. We did not observe any light-dependent changes of the free cytosolic Caz+ concen...
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ژورنال
عنوان ژورنال: Neuron
سال: 2001
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(01)00299-9